Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 9th Edition

Part I: Structural and Molecular Bases of Ion Channel Function
1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart
2. Voltage-Gated Calcium Channels
3. Voltage-Gated Potassium Channels
4. Molecular Regulation of Cardiac Inward Rectifier Potassium Channel
5. Mammalian Calcium Pumps in Health and Disease
6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function
7. Organellar Ion Channels and Transporters
8. Molecular Organization, Gating, and Function of Connexin-Based Gap Junction Channels and Hemichannels

Part II: Biophysics of Cardiac Ion Channel Function
9. Voltage-Gated Sodium Channels with Open and Closed Gates: Implications for State-Dependent Drug Design
10. Regulation of Cardiac Calcium Channels
11. Molecular Genetics of ATP-Sensitive K+ Channels in Cardiovascular Diseases
12. Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity
13. Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels
14. Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance
15. Connexins and Pannexins in Cardiovascular Disease
16. Excitation-Contraction Coupling

Part III: Intermolecular Interactions and Cardiomyocyte Electrical Function
17. Ion Channel Trafficking in the Heart
18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5
19. Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels
20. Macromolecular Complexes and Cardiac Potassium Channels
21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias
22. The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion and Cell Excitability
23. Function and Dysfunction of Ion Channel Membrane Trafficking and Post Translational Modification
24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling

Part IV: Cell Biology of Cardiac Impulse Initiation and Propagation
25. Coupled Oscillators and Sinoatrial Pacemaker Activity
26. Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants
27. Cell-to-Cell Communication and Impulse Propagation
28. Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation
29. Cell Biology of the Specialized Cardiac Conduction System

Part V: Models of Cardiac Excitation
30. Prediction of Drug-Induced Arrhythmia Using Machine Learning
31. Global Optimization Approaches to Generate Dynamically Robust Electrophysiological Models
32. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries
33. Theory of Rotors and Arrhythmias
34. Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers
35. Computational Approaches for Accurate Rotor localization in the Human Atria
36. Modeling the Aging Heart
37. Electromechanical Vortex Filaments During Cardiac Fibrillation

Part VI: Neural Control of Cardiac Electrical Activity
38. Innervation of the Sinoatrial Node
39. Mechanisms for Altered Autonomic and Oxidant Regulation of Cardiac Sodium Currents
40. Neural Activity and Atrial Tachyarrhythmias
41. Sympathetic Modulation of Cardiac Electrophysiology
42. Role of the Autonomic Nervous System in Atrial Fibrillation

Part VII: Arrhythmia Mechanisms
43. Rotors in Human Atrial Fibrillation
44. Nonivasive Frequency-Phase Mapping of Atrial Fibrillation
45. Electrical Biomarkers of the Progression of Atrial Fibrillation
46. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation
47. Genetics of Atrial Fibrillation

Part VIII: Molecular Genetics and Pharmacogenomics
48. Mechanisms in Heritable Sodium Channel Diseases
49. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes
50. Inheritable Potassium Channel Diseases
51. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation

Part IX: Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction
52. Upstream therapy to prevent AF progression
53. Pharmacogenomics of Cardiac Arrhythmias
54. Screening Drugs for Myocardial Disease in Vivo with Zebrafish
55. Gene Therapy for Atrial Fibrillation

Part X: Cell biology and electrophysiology of human induced pluripotent stem cell derived cardiomyocytes
56. Cardiac Remodeling and Regeneration
57. High-Throughput Optical Mapping of 2 and 3-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing
58. Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors
59. Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Part XI: Diagnostic Evaluation
60. Assessment of the Patient With a Cardiac Arrhythmia
61. Differential Diagnosis of Narrow and Wide Complex Tachycardias
62. Electrocardiographic Monitoring: Short, Long-Term Recording
63. Personal Cardiac Monitoring
64. Computed Tomography for Electrophysiology
65. Magnetic Resonance Imaging for Electrophysiology
66. Intracardiac Echocardiography for Electrophysiology
67. Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk
68. Non-invasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Arrhythmias
69. Genetic Testing

Part XII: Supraventricular Arrhythmias: Diagnosis and Therapy
70. Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory
71. Atrial Tachycardia
72. Atrioventricular Nodal Reentrant Tachycardia
73. Junctional Tachycardia
74. Preexcitation, Atrioventricular Reentry, Variants
75. Atrial Fibrillation: Mechanisms, Clinical Features, and Management
76. Ablation for Atrial Fibrillation
77. Left Atrial Appendage Management
78. Typical and Atypical Atrial Flutter: Mapping and Ablation

Part XIII: Ventricular Arrhythmias
79. Sudden Cardiac Death in Adults
80. Premature Ventricular Complexes
81. Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management
82. PVC Ablation with Anatomic Guidance: Papillary Muscle, Moderator Band and Valve Annulus Sites
83. Fascicular Ventricular Arrhythmias
84. Bundle Branch Reentry Tachycardia
85. Ventricular Arrhythmias in Ischemic Heart Disease
86. Ablation of Post-Myocardial Infarction VT
87. Ventricular Tachycardia in Patients with Dilated Cardiomyopathy
88. Lamin A/C, Noncompaction and Other Genetic Cardiomyopathies with Ventricular Arrhythmias
89. Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators
90. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
91. Catecholaminergic Polymorphic Ventricular Tachycardia
92. Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy
93. Ventricular Arrhythmias in Takotsubo Cardiomyopathy
94. Mitral Valve Prolapse, ventricular arrhythmias and Sudden Death
95. Brugada Syndrome
96. Long and Short QT Syndromes
97. Andersen-Tawil Syndrome
98. Timothy Syndrome
99. J-Wave Syndromes
100. Idiopathic Ventricular Fibrillation
101. Mapping and Ablation of Ventricular Fibrillation
102. Drug-Induced Ventricular Arrhythmias

Part XIV: Syncope and Bradyarrhythmias
103. Syncope
104. Sinus Node Abnormalities
105. Postural Orthostatic Tachycardia Syndrome
106. Atrioventricular Block

Part XV: Arrhythmias in Special Populations
107. Sex Differences in Arrhythmias
108. Sudden Cardiac Deaths in Athletes, Including Commotio Cordis
109. Cardiac Sarcoidosis
110. Sleep-Disordered Breathing and Arrhythmias
111. Ventricular Assist Devices and Cardiac Transplantation Recipients
112. Arrhythmia in Neurologic Disease
113. Cancer Therapy Related Arrhythmias

Part XVI: Congenital Heart Disease and Pediatrics
114. Arrhythmias in the Pediatric Population
115. Supraventricular Tachycardias in Congenital Heart Disease
116. Ventricular Arrhythmias in Congenital Heart Disease

Part XVII: Pharmacologic Therapy
117. Antiarrhythmic Drugs
118. Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death
119. Oral Anticoagulants

Part XVIII: Devices for Arrhythmia Management
120. Implantable Pacemakers
121. Implantable Cardioverter Defibrillators: Technical Aspects
122. Implantable Cardioverter Defibrillators: Clinical Aspects
123. Subcutaneous Implantable Cardioverter Defibrillators
124. Wearable Defibrillators
125. Cardiac Resynchronization Therapy
126. Management of Implanted Device Infections

Part XIX: Catheter and Surgical Mapping and Ablation
127. Electrogram Recording and Signal Processing
128. Electroanatomic Mapping for Arrhythmias
129. Mapping Scar-Related Arrhythmias
130. Radiofrequency Ablation
131. Cryoablation and Other Radiofrequency Alternatives
132. Transvascular Ethanol Ablation
133. Stereotactic Radioablation
134. Percutaneous Epicardial Access, Mapping and Ablation
135. Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias
136. Surgery for Ventricular Arrhythmias
137. Neuromodulation for the Treatment of Arrhythmias

Jose Jalife, MD, PhD, Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA and William Gregory Stevenson, MD, Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women's Hospital; Professor of Medicine Harvard Medical School, Boston, MA, USA