Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 9th Edition

Part I: Structural and Molecular Bases of Ion Channel Function
1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart
2. Voltage-Gated Calcium Channels
3. Voltage-Gated Potassium Channels
4. Molecular Regulation of Cardiac Inward Rectifier Potassium Channel
5. Mammalian Calcium Pumps in Health and Disease
6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function
7. Organellar Ion Channels and Transporters
8. Molecular Organization, Gating, and Function of Connexin-Based Gap Junction Channels and Hemichannels

Part II: Biophysics of Cardiac Ion Channel Function
9. Voltage-Gated Sodium Channels with Open and Closed Gates: Implications for State-Dependent Drug Design
10. Regulation of Cardiac Calcium Channels
11. Molecular Genetics of ATP-Sensitive K+ Channels in Cardiovascular Diseases
12. Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity
13. Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels
14. Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance
15. Connexins and Pannexins in Cardiovascular Disease
16. Excitation-Contraction Coupling

Part III: Intermolecular Interactions and Cardiomyocyte Electrical Function
17. Ion Channel Trafficking in the Heart
18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5
19. Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels
20. Macromolecular Complexes and Cardiac Potassium Channels
21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias
22. The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion and Cell Excitability
23. Function and Dysfunction of Ion Channel Membrane Trafficking and Post Translational Modification
24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling

Part IV: Cell Biology of Cardiac Impulse Initiation and Propagation
25. Coupled Oscillators and Sinoatrial Pacemaker Activity
26. Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants
27. Cell-to-Cell Communication and Impulse Propagation
28. Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation
29. Cell Biology of the Specialized Cardiac Conduction System

Part V: Models of Cardiac Excitation
30. Prediction of Drug-Induced Arrhythmia Using Machine Learning
31. Global Optimization Approaches to Generate Dynamically Robust Electrophysiological Models
32. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries
33. Theory of Rotors and Arrhythmias
34. Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers
35. Computational Approaches for Accurate Rotor localization in the Human Atria
36. Modeling the Aging Heart
37. Electromechanical Vortex Filaments During Cardiac Fibrillation

Part VI: Neural Control of Cardiac Electrical Activity
38. Innervation of the Sinoatrial Node
39. Mechanisms for Altered Autonomic and Oxidant Regulation of Cardiac Sodium Currents
40. Neural Activity and Atrial Tachyarrhythmias
41. Sympathetic Modulation of Cardiac Electrophysiology
42. Role of the Autonomic Nervous System in Atrial Fibrillation

Part VII: Arrhythmia Mechanisms
43. Rotors in Human Atrial Fibrillation
44. Nonivasive Frequency-Phase Mapping of Atrial Fibrillation
45. Electrical Biomarkers of the Progression of Atrial Fibrillation
46. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation
47. Genetics of Atrial Fibrillation

Part VIII: Molecular Genetics and Pharmacogenomics
48. Mechanisms in Heritable Sodium Channel Diseases
49. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes
50. Inheritable Potassium Channel Diseases
51. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation

Part IX: Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction
52. Upstream therapy to prevent AF progression
53. Pharmacogenomics of Cardiac Arrhythmias
54. Screening Drugs for Myocardial Disease in Vivo with Zebrafish
55. Gene Therapy for Atrial Fibrillation

Part X: Cell biology and electrophysiology of human induced pluripotent stem cell derived cardiomyocytes
56. Cardiac Remodeling and Regeneration
57. High-Throughput Optical Mapping of 2 and 3-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing
58. Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors
59. Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Part XI: Diagnostic Evaluation
60. Assessment of the Patient With a Cardiac Arrhythmia
61. Differential Diagnosis of Narrow and Wide Complex Tachycardias
62. Electrocardiographic Monitoring: Short, Long-Term Recording
63. Personal Cardiac Monitoring
64. Computed Tomography for Electrophysiology
65. Magnetic Resonance Imaging for Electrophysiology
66. Intracardiac Echocardiography for Electrophysiology
67. Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk
68. Non-invasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Arrhythmias
69. Genetic Testing

Part XII: Supraventricular Arrhythmias: Diagnosis and Therapy
70. Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory
71. Atrial Tachycardia
72. Atrioventricular Nodal Reentrant Tachycardia
73. Junctional Tachycardia
74. Preexcitation, Atrioventricular Reentry, Variants
75. Atrial Fibrillation: Mechanisms, Clinical Features, and Management
76. Ablation for Atrial Fibrillation
77. Left Atrial Appendage Management
78. Typical and Atypical Atrial Flutter: Mapping and Ablation

Part XIII: Ventricular Arrhythmias
79. Sudden Cardiac Death in Adults
80. Premature Ventricular Complexes
81. Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management

Jose Jalife, MD, PhD, Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA and William Gregory Stevenson, MD, Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women's Hospital; Professor of Medicine Harvard Medical School, Boston, MA, USA